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In contrast, for drugs undergoing phase II metabolism, a drug interaction via efflux transporter inhibition could lead to higher plasma levels of metabolite with or without a corresponding increase in the aglycone levels, even though the enzyme activities were not altered (Yang et al., 2012

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To reflect the contribution of each SCENITH pathway percentual measurements with respect to total protein synthesis over time, we multiplied each SCENITH parameter by gMFI of puromycin MFI accounting for the changes in background levels according to the following formula: [(SCENITH parameter)*(C-DGO)] (Fig