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However, when antioxidative systems become saturated, RBCs accumulate oxidative lesions, provoking biochemical alterations and advancing pathological developments ( 2 O 2 can diffuse out of erythrocytes and provoke inflammatory activation in the lung’s microvascular endothelium ( 2 O 2 and hydroxyl radicals inflict damage on erythrocyte membrane proteins and lipids, resulting in reorganization of the cytoskeleton, loss of membrane stability and deformability, and eventually eryptosis (Sudnitsyna et al., 2020)

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Discussion This single-center retrospective study, conducted at a tertiary hospital in Western China, employed chi-square tests to evaluate 154 warfarin-treated patients, focusing on: (1) international normalized ratio (INR) target attainment rates, (2) incidence of treatment-related complications, and (3) associated risk factors