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Vitamin B12 absorption from food requires several steps: intrinsic factor secretion from gastric parietal cells, acid-dependent release of B12 from food proteins, and physical contact time in the ileum where transcobalamin receptors capture the B12-intrinsic factor complex

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Why Short Half-Lives Aren't Necessarily a Problem A common misconception is that "longer half-life is always better." For research protocols, this isn't the case