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Elevated histamine levels in the lungs cause inflammatory cytokine release.[ref] Histamine levels and mast cell activation cause bronchial constriction in COPD.[ref][ref] Brain fog: High histamine levels can be a cause of brain fog or cognitive issues Canker sores, oral lesions, or burning mouth.[ref] Periodic Limb Movement Disorder: Animal studies show that H3 receptor activation causes limb movements during sleep Autoinflammatory conditions, such as familial Mediterranean fever: People with FMF have higher-than-normal histamine levels during a flare-up

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To bridge these gaps, future research must prioritize large-scale, multicenter RCTs to establish reliable clinical efficacy and rigorously evaluate long-term safety and drug interactions