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For instance, the gene products of glycoproteins J and D (gJ, gD) have been reported to modulate cellular apoptosis during HSV-1 infection of the SK-N-SH human neuron cell line (neuroblastoma), as mutant viruses lacking any of the genes encoding for these proteins led to cell apoptosis early after infection, which was abolished when gD and gJ were complemented in trans (Zhou et al., 2000)

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Current treatments, such as steroid creams and light therapy, are not reliably effective in reversing the disease