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COVID-19 virus has been shown to cause 1 or elevate 2 ER stress in the course of disease, and a trusted therapy of respiratory infections, Lian Hua Qing Wen, has been proved to attenuate lung injury through inhibiting ER stress 3

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These include sustained low-grade systemic inflammation, dysregulated immune responses, and disruptions in gut-derived metabolic and signaling pathways, particularly those involving the gut–brain and gut–lung axes [75,93]